γδ T cells modulate anti-tumor immunity in small cell lung cancer
Ng, J.; You, Y.; Zhang, T. Z.; Hess, J. B.; Best, S. A.; Caneborg, A.; Schmiel, M.; Godfrey, D. I.; Wu, Y.; Tothill, R. W.; Antilla, C. J. A.; Baldwin, T. M.; Naik, S. H.; Amman-Zalcenstein, D.; Kersbergen, A. J.; Leong, T. L.; George, J.; Ritchie, M. E.; Gherardin, N. A.; Koay, H.-F.; Hickey, P. F.; Steinfort, D.; Sutherland, K. D.
Show abstract
Small cell lung cancer (SCLC) is a highly aggressive neoplasm with limited sensitivity to anti-PD-(L)1 blockade, likely due to the epigenetic silencing of MHC-I. Elucidating MHC-I-independent immune recognition mechanisms is therefore crucial for enhancing treatment responses and improving clinical outcomes in a greater number of patients. Leveraging single cell approaches, we discovered {gamma}{delta} T cell infiltration in biospecimens from patients with SCLC. Despite PD-1 expression, {gamma}{delta} T cells maintained a cytotoxic transcriptional profile, suggestive of an anti-tumor role. Indeed, high {gamma}{delta} T cell infiltration predicted improved response to anti-PD-L1 immunotherapy in patients with SCLC. Moreover, using pre-clinical models, we demonstrated that {gamma}{delta} T cells are effective at tarlatamab (DLL3-CD3 BiTE) redirected SCLC killing and that zoledronate, an FDA-approved compound, can sensitize SCLC cells to {gamma}{delta} T cell-mediated killing. Thus, our findings suggest that engaged {gamma}{delta} T cells are potentially valuable targets for SCLC therapy.
Matching journals
The top 6 journals account for 50% of the predicted probability mass.
Similar papers in this journal
Similar papers in this journal
- Cell lineage as a predictor of immune response in neuroblastoma 95%
- Combined KRASG12C and SOS1 inhibition enhances and extends the anti-tumor response in KRASG12C-driven cancers by addressing intrinsic and acquired resistance 94%
- Metastasis founder cells activate immunosuppression early in human melanoma metastatic colonization 94%
Similar papers in this journal
- Generation of a biliary tract cancer cell line atlas reveals molecular subtypes and therapeutic targets 95%
- Multimodal Spatial Profiling Reveals Immune Suppression and Microenvironment Remodeling in Fallopian Tube Precursors to High-Grade Serous Ovarian Carcinoma 95%
- PTP1B is an intracellular checkpoint that limits T cell and CAR T cell anti-tumor immunity 95%
Similar papers in this journal
- Targeting the mSWI/SNF Complex in POU2F-POU2AF Transcription Factor-Driven Malignancies 95%
- Lymphocyte networks are dynamic cellular communities in the immunoregulatory landscape of lung adenocarcinoma 94%
- An mRNA-encoded, long-lasting Interleukin-2 restores CD8+ T cell neoantigen immunity in MHC class I-deficient cancers 94%
"Similar papers" are the closest papers from that journal in the model's embedding space. They show what the match is built on, but the ranking comes mostly from a classifier over the whole training set, not from these examples alone.