Impact of Vitamin D on Gene Expression in Atlantic Salmon Skin and Potential Immunomodulation Against Salmon Louse Infection
Taylor, L. D.; Gorman, C. E.; Egan, F.; Ruane, N. M.; McGinnity, P. D.; Hulsey, C. D.
Show abstract
Vitamin D is a key micronutrient in vertebrate health that influences musculoskeletal function and likely modulates immune responses in tissues such as the skin. In aquaculture, Atlantic salmon (Salmo salar) are particularly vulnerable to skin pathogens, notably the ectoparasitic salmon louse (Lepeophtheirus salmonis). As the skin represents the first line of immunological defence, its capacity to mediate host-pathogen interactions may be influenced by dietary vitamin D. This study investigated the transcriptomic response of salmon skin following six months of dietary vitamin D supplementation, with a focus on immune-related gene expression. A total of 113 differentially expressed genes (DEGs) were identified, 46 of which are implicated in inflammation, immune signalling, and both innate and adaptive immunity. These DEGs were further compared to published RNA-seq data of salmon skin challenged with L. salmonis. Notably, while pro-inflammatory genes were regulated in opposing directions, heat shock proteins, lysozyme and antimicrobial peptides were consistently upregulated under both conditions. These findings suggest that vitamin D may modulate cutaneous immune responses by dampening inflammation and enhancing innate defences, potentially improving resistance to skin-associated pathogens such as salmon lice.
Matching journals
The top 9 journals account for 50% of the predicted probability mass.
Similar papers in this journal
- Comparative transcriptomics reveals domestication-associated features of Atlantic salmon lipid metabolism 95%
- Daphnia magna modifies its gene expression extensively in response to caloric restriction revealing a novel effect on haemoglobin isoform preference 94%
- Density-dependent expression of epitranscriptomic, stress, and appetite regulating genes in Atlantic salmon 94%
Similar papers in this journal
- Characterising the mechanisms underlying genetic resistance to amoebic gill disease in Atlantic salmon using RNA sequencing 95%
- Investigating mechanisms underlying genetic resistance to Salmon Rickettsial Syndrome in Atlantic salmon using RNA sequencing 92%
- Transcriptome analysis provides genome annotation and expression profiles in the central nervous system of Lymnaea stagnalis at different ages 92%
Similar papers in this journal
- Vitamins D 2 and D 3 have overlapping but different effects on human gene expression revealed through analysis of blood transcriptomes in a randomised double-blind placebo-controlled food-fortification trial 93%
- Early life glucocorticoid exposure modulates immune function in zebrafish (Danio rerio) larvae 93%
- Integrative Transcriptomic Analysis Reveals the Immune Mechanism for A CyHV-3-Resistant Common Carp Strain 91%
Similar papers in this journal
- Comparative genomic analysis of three salmonid species identifies functional candidate genes involved in resistance to the intracellular bacteria Piscirickettsia salmonis 91%
- Development of a high-density 665 K SNP array for rainbow trout genome-wide genotyping 90%
- Gut transcriptome reveals differential gene expression and enriched pathways linked to immune activation in response to weaning in pigs. 90%
Similar papers in this journal
- Genomic and functional gene studies suggest a key role of beta-carotene oxygenase 1 like (bco1l) gene in salmon flesh color. 93%
- Genome-scale comparative analysis for host resistance against sea lice between Atlantic salmon and rainbow trout 93%
- Metabolomics shows the Australian dingo has a unique plasma profile 92%
"Similar papers" are the closest papers from that journal in the model's embedding space. They show what the match is built on, but the ranking comes mostly from a classifier over the whole training set, not from these examples alone.