Immune cell de novo steroidogenesis regulates inflammation resolution and recovery in acute lung injury
Hussein, H. A. M.; Shaji, S. K.; Veiga-Villauriz, C.; Chakraborty, S.; Pramanik, J.; Ali, F. A. Z.; Yuan, J.; Khanfar, E.; Makuyana, N.; Ali, Y. M.; Zhao, Q.; Hebenstreit, D.; Mahata, B.
Show abstract
Effective resolution of inflammation following acute lung infection or injury is critical for restoring immune and tissue homeostasis to ensure functional recovery. Prolonged or unresolved inflammation can impair lung repair, promote fibrosis, and contribute to pulmonary dysfunction. While systemic steroid signalling is known to modulate general immune responses, the specific role of immune cell-mediated steroidogenesis in regulating lung inflammation and repair remains unknown. Here, we show that immune cell de novo steroidogenesis is essential for resolving inflammation and promoting recovery in a murine model of acute lung injury. During the resolution phase, steroid-synthesizing immune cells, predominantly basophils, are enriched in the lung. Mice with immune cell-specific ablation of de novo steroidogenesis exhibit exacerbated lung injury, impaired resolution of inflammation, and defective tissue repair. These findings reveal a previously unrecognized immunoregulatory function of immune cell-derived steroids and identify immune cell steroidogenesis as a potential therapeutic target for promoting resolution and recovery in inflammatory lung diseases.
Matching journals
The top 5 journals account for 50% of the predicted probability mass.
Similar papers in this journal
- Similarities and differences between IL11 and IL11RA1 knockout mice for lung fibro-inflammation, fertility and craniosynostosis 94%
- Epithelial Remodeling And Microbial Dysbiosis In The Lower Respiratory Tract Of Vitamin A-Deficient Mouse Lungs 94%
- Therapeutic Targeting of 15-PGDH in Murine Idiopathic Pulmonary Fibrosis 93%
Similar papers in this journal
Similar papers in this journal
- A Novel Humanized Mouse Model for HIV and Tuberculosis Co-infection Studies 94%
- Differential Immunoregulation by Human Surfactant Protein A Variants Determines Severity of SARS-CoV-2-induced Lung Disease 94%
- Identification of a novel HIF-1α-αMβ2 Integrin-NETosis axis in fibrotic interstitial lung disease 93%
Similar papers in this journal
- MME+ fibro-adipogenic progenitors are the dominant adipogenic population during fatty infiltration in human skeletal muscle 92%
- Defining the cardiac fibroblast secretome in the healthy and infarcted mouse heart 92%
- Partial inhibition of mitochondrial complex I attenuates neurodegeneration and restores energy homeostasis and synaptic function in a symptomatic Alzheimers mouse model 92%
"Similar papers" are the closest papers from that journal in the model's embedding space. They show what the match is built on, but the ranking comes mostly from a classifier over the whole training set, not from these examples alone.