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Developmental Glymphatic Dysfunction Underlies Excitation/Inhibition Imbalance and Psychosis Vulnerability in 22q11.2 Deletion Syndrome
2025-09-02
psychiatry and clinical psychology
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BackgroundImpairment of the glymphatic system may contribute to atypical brain development and increased vulnerability to psychiatric conditions such as psychosis. In particular, disrupted glymphatic efficiency may affect neurochemical homeostasis during critical maturational windows, leading to structural and circuit-level alterations. However, its role in early neurodevelopmental trajectories remains largely unexplored. MethodsWe combined longitudinal diffusion tensor imaging (DTI) and magnet...
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