Back

Single-cell genetics identifies cell type-specific causal mechanisms in complex traits and diseases

2025-08-29 genetic and genomic medicine Title + abstract only
View on medRxiv
Show abstract

Genome-wide association studies (GWAS) have been instrumental in uncovering the genetic basis of complex traits. When integrated with expression quantitative trait loci (eQTL) mapping, they can elucidate how risk loci influence traits through gene regulatory mechanisms. Recent single-cell eQTL (sc-eQTL) studies suggest that genetic effects on gene expression are often cell type- and subtype-specific, but such datasets have so far been underpowered for causal inference. Here, we leverage results ...

Predicted journal destinations

1
Nature Communications
483 training papers
#1 34.1%
2
Nature Genetics
72 training papers
Top 1% 8.6%
3
The American Journal of Human Genetics
77 training papers
Top 3% 7.0%
4
Genome Medicine
56 training papers
Top 0.6% 7.0%
5
Cell Genomics
34 training papers
Top 0.3% 4.2%
6
Nature
58 training papers
Top 0.5% 3.1%
7
Human Genetics and Genomics Advances
39 training papers
Top 3% 2.1%
8
Scientific Reports
701 training papers
Top 77% 2.1%
9
eLife
262 training papers
Top 19% 2.1%
10
Proceedings of the National Academy of Sciences
100 training papers
Top 7% 1.7%
11
Human Molecular Genetics
28 training papers
Top 3% 1.7%
12
Nature Medicine
88 training papers
Top 4% 1.7%
13
Genetics in Medicine
57 training papers
Top 6% 1.5%
14
PLOS Genetics
39 training papers
Top 5% 1.5%
15
iScience
74 training papers
Top 7% 1.3%
16
Communications Biology
36 training papers
Top 3% 1.1%
17
Frontiers in Genetics
32 training papers
Top 6% 1.0%
18
Annals of the Rheumatic Diseases
23 training papers
Top 1.0% 1.0%
19
Journal of Clinical Investigation
50 training papers
Top 4% 1.0%
20
Frontiers in Immunology
140 training papers
Top 10% 1.0%
21
JCI Insight
63 training papers
Top 8% 0.8%
22
Arthritis & Rheumatology
21 training papers
Top 1% 0.5%
23
Translational Psychiatry
94 training papers
Top 12% 0.5%
24
Bioinformatics
24 training papers
Top 5% 0.5%
25
Circulation: Genomic and Precision Medicine
30 training papers
Top 8% 0.5%
26
Communications Medicine
63 training papers
Top 10% 0.5%
27
European Journal of Human Genetics
25 training papers
Top 6% 0.5%
28
Brain
69 training papers
Top 12% 0.5%
29
International Journal of Molecular Sciences
39 training papers
Top 9% 0.5%
30
Genes
21 training papers
Top 6% 0.5%