Effects of Psychedelic Drug Use on Neurocognitive Function and Psychological and Social Quality of Life Domains: An International Online Study
Stadler, F.; Saelens, J.; Henter, I.; Rieser, N.; Greenwald, M.; Ballard, E. D.; Preller, K. H.; Zarate, C. A.; Kraus, C.
Show abstract
This international online study (N=759) examined the acute, subacute, and long-term effects of psychedelic drug use on cognitive performance and mental health. Participants completed cognitive tasks assessing working memory, selective attention, and visual/spatial perception, as well as questionnaires assessing mental health outcomes and quality of life. Based on self-reported substance use, participants were classified as non-users, lifetime users, and recent users. Recent users had significantly lower accuracy across all cognitive tasks, and lifetime users had the highest task accuracy without corresponding reaction time deficits. Lifetime use was not associated with long-term cognitive decline. Recent users reported more depressive and dissociative symptoms, whereas lifetime users reported lower scores. Lifetime users scored lower on psychological and social quality of life domains, indicating possible long-term psychosocial effects. These findings highlight the need to differentiate between the acute and long-term effects of psychedelics; lab-controlled, longitudinal studies are needed to enable safe clinical application.
Matching journals
The top 8 journals account for 50% of the predicted probability mass.
Similar papers in this journal
- Drug-drug interactions between classic psychedelics and psychoactive drugs: a systematic review 95%
- Incident benzodiazepine and Z-drug use and subsequent risk of alcohol- and drug-related problems: a nationwide matched cohort study with co-twin comparison 94%
- How does it feel to be on psilocybin? Dose-response relationships of subjective experiences in humans. 94%
Similar papers in this journal
- Differential alterations in peripheral tryptophan pathways in methamphetamine versus MDMA users are linked to their contrasting psychiatric symptoms 95%
- Cue-induced cocaine craving enhances psychosocial stress and vice versa in chronic cocaine users 94%
- Association Patterns of Antisocial Personality Disorder across Substance Use Disorders 93%
Similar papers in this journal
- Association of extent of cannabis use and psychotic like intoxication experiences in a multi-national sample of First Episode Psychosis patients and controls 95%
- A single dose of lamotrigine induces a positive memory bias in healthy volunteers 94%
- Sociodemographic, clinical, and genetic factors associated with self-reported antidepressant response outcomes in the UK Biobank 93%
Similar papers in this journal
- Psychedelic mushrooms in the USA: Knowledge, patterns of use and association with health outcomes 96%
- Patients with affective disorders profit most from telemedical treatment: Evidence from a naturalistic patient cohort during the COVID-19 pandemic 92%
- Reorganization of Substance Use Treatment and Harm Reduction Services during the COVID-19 Pandemic: A Global Survey 92%
Similar papers in this journal
- Effects of cannabis use on antidepressant treatment response to repetitive transcranial magnetic stimulation and ketamine 96%
- Low dose oral ketamine treatment on post-traumatic stress disorder (PTSD) (OKTOP): An open-label pilot study 95%
- Comparative analysis of anticholinergic burden scales to explain iatrogenic cognitive impairment and self-reported side effects in the euthymic phase of bipolar disorders: results from the FACE-BD cohort 93%
"Similar papers" are the closest papers from that journal in the model's embedding space. They show what the match is built on, but the ranking comes mostly from a classifier over the whole training set, not from these examples alone.