Back
#1
18.7%
Top 1%
18.7%
Top 0.3%
12.4%
Top 3%
6.3%
Top 61%
4.4%
Top 26%
4.1%
Top 14%
3.3%
Top 1%
2.9%
Top 3%
2.9%
Top 3%
2.9%
Top 91%
2.0%
Top 3%
2.0%
Top 6%
2.0%
Top 2%
2.0%
Top 1%
2.0%
Top 26%
1.0%
Top 22%
0.8%
Top 16%
0.8%
Top 4%
0.8%
Top 22%
0.8%
Haplotype Targeting in Heart Failure Using a Biased Ligand β-blocker
2025-08-24
cardiovascular medicine
Title + abstract only
View on medRxiv
Show abstract
BackgroundADRB1 and ADRB2, encoding cardiac myocyte {beta}1- and {beta}2-adrenergic receptors (ARs) that mediate pathologic myocardial remodeling in response to chronically increased signaling, contain N-terminus haplotype variants capable of influencing agonist- or biased ligand-induced receptor internalization that uncouples canonical signaling and initiates EGFR/ERK1/2 cardioprotection. MethodsIn two heart failure (HF) clinical trial genetic substudies we investigated effects of internalizin...
Predicted journal destinations
1
Circulation
37 training papers
2
Journal of the American Heart Association
92 training papers
3
Circulation: Genomic and Precision Medicine
30 training papers
4
Frontiers in Cardiovascular Medicine
33 training papers
5
Scientific Reports
701 training papers
6
Nature Communications
483 training papers
7
eLife
262 training papers
8
European Heart Journal - Digital Health
15 training papers
9
Open Heart
18 training papers
10
The American Journal of Cardiology
15 training papers
11
PLOS ONE
1737 training papers
12
Heart Rhythm
16 training papers
13
Nature Genetics
72 training papers
14
Hypertension
20 training papers
15
Atherosclerosis
16 training papers
16
BMC Medicine
155 training papers
17
PLOS Medicine
95 training papers
18
Nature Medicine
88 training papers
19
Frontiers in Physiology
18 training papers
20
Journal of Clinical Medicine
77 training papers