Identification of robust mortality-associated neutrophil gene programs and cytokine responses using large-scale ARDS endotracheal aspirate scRNA-seq data

2025-08-24 intensive care and critical care medicine Title + abstract only

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Myeloid dysregulation is involved in severe Acute Respiratory Distress Syndrome (ARDS), but the mechanistic understanding is still incomplete. We analyzed endotracheal aspirate (ETA) scRNA-seq data from 40 intubated patients (both COVID-19 and non-COVID-19) in the COMET cohort, to uncover cell types and gene programs associated with ARDS mortality. In cell-type-agnostic analyses, we identified neutrophils as a critical cell type prognostic for ARDS mortality. Subsequent analyses uncovered a mort...

Identification of robust mortality-associated neutrophil gene programs and cytokine responses using large-scale ARDS endotracheal aspirate scRNA-seq data

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