Back

Redefining ALS: Large-scale proteomic profiling reveals a prolonged pre-diagnostic phase with immune, muscular, metabolic, and brain involvement

2025-08-28 neurology Title + abstract only
View on medRxiv
Show abstract

BackgroundAmyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disorder with a largely unknown duration and pathophysiology of the pre-diagnostic phase, especially for the common non-monogenic form. MethodsWe leveraged the European Prospective Investigation into Cancer and Nutrition (EPIC) cohort with up to 30 years of follow-up to identify incident ALS cases across five European countries. Pre-diagnostic plasma samples from initially healthy participants underwent high-throughput p...

Predicted journal destinations

1
Brain
69 training papers
Top 0.5% 11.4%
2
Alzheimer's & Dementia
84 training papers
Top 2% 8.7%
3
Movement Disorders
49 training papers
Top 1% 8.7%
4
Annals of Neurology
43 training papers
#1 7.5%
5
Brain Communications
79 training papers
Top 1% 7.5%
6
Journal of Neurology, Neurosurgery & Psychiatry
26 training papers
Top 0.2% 5.7%
7
Nature Communications
483 training papers
Top 20% 5.7%
8
npj Parkinson's Disease
35 training papers
Top 1% 4.0%
9
Journal of Neurology
22 training papers
Top 0.2% 4.0%
10
Neurology
38 training papers
Top 3% 3.7%
11
eBioMedicine
82 training papers
Top 0.8% 2.7%
12
Neurobiology of Aging
29 training papers
Top 2% 1.9%
13
Alzheimer's Research & Therapy
31 training papers
Top 3% 1.9%
14
Frontiers in Neurology
74 training papers
Top 9% 1.5%
15
Annals of Clinical and Translational Neurology
22 training papers
Top 2% 1.5%
16
Scientific Reports
701 training papers
Top 87% 1.5%
17
Parkinsonism & Related Disorders
16 training papers
Top 2% 1.5%
18
NeuroImage: Clinical
77 training papers
Top 8% 1.5%
19
Journal of Alzheimer's Disease
31 training papers
Top 4% 1.3%
20
European Journal of Neurology
20 training papers
Top 4% 1.1%
21
Alzheimer's & Dementia: Diagnosis, Assessment & Disease Monitoring
28 training papers
Top 3% 1.1%
22
eLife
262 training papers
Top 40% 1.1%
23
Molecular Psychiatry
84 training papers
Top 8% 1.1%
24
Journal of Alzheimer’s Disease
23 training papers
Top 3% 0.9%
25
Multiple Sclerosis Journal
15 training papers
Top 2% 0.9%
26
Human Brain Mapping
53 training papers
Top 11% 0.7%
27
EBioMedicine
21 training papers
Top 1% 0.7%
28
EMBO Molecular Medicine
15 training papers
Top 1% 0.7%
29
PLOS ONE
1737 training papers
Top 99% 0.7%
30
Frontiers in Aging Neuroscience
22 training papers
Top 5% 0.7%