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Distinct roles of hippocampus and neocortex in symbolic compositional generalization

liang, z.; Glitz, L.; Hefner, M. B.; Lan, D.; Klein-Flugge, M.; Summerfield, C.

2025-08-20 neuroscience
10.1101/2025.08.19.671090 bioRxiv
Show abstract

Humans can combine symbols to generate new meanings. Here, we studied the regional neural mechanisms that might make this possible. We asked participants to combine two discrete, symbolic features (a shape and a colour) to make a novel spatial inference. BOLD data suggested that the hippocampus encoded elementary visual attributes in a high-dimensional, parallel format that permitted flexible individuation. In ventromedial prefrontal cortex (vmPFC), posterior parietal cortex (PPC) and primary visual cortex (V1), neural patterns for novel stimuli (composites) could be predicted as a linear combination of signals for familiar stimuli (elements). In vmPFC, this composition occurred in a high-dimensional format, but in PPC and V1, it took place in a low-dimensional, spatial, response-consistent frame of reference. These data offer new insights into the neural circuit underlying compositional generalization.

Published in Neuron (predicted rank #2) · training set

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