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Single-cell mass spectrometry imaging combined with immunofluorescence reveals neutrophil heterogeneity in inflammation

Bessler, S.; Richter, M.; Schwenzfeier, J.; Reinartz Groba, S. N.; Trebicka, J.; Dreisewerd, K.; Soltwisch, J.; Soehnlein, O.

2025-08-22 immunology
10.1101/2025.08.19.671021 bioRxiv
Show abstract

Multimodal single-cell approaches allow for a holistic analysis of complex biological systems. In this study, we developed a novel single-cell analysis pipeline integrating immunofluorescence-based protein with mass spectrometry imaging-based lipid analysis of circulating human neutrophils. The combination of both modalities identified the emergence of pathogenic neutrophils in liver cirrhosis patients thus epitomizing the potential of this technology to reveal cellular phenotypes in health and disease.

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"Similar papers" are the closest papers from that journal in the model's embedding space. They show what the match is built on, but the ranking comes mostly from a classifier over the whole training set, not from these examples alone.