A Phosphorelay Circuit Drives Extracellular Alkalinization in Plant Receptor Kinase Signaling
Zhai, K.; Derbyshire, P.; Zhang, S.; Choi, S.; Wang, L.; Song, B.; Kinoshita, T.; Zhou, J.-M.; Menke, F.; Bender, K. W.; Zipfel, C.
Show abstract
Extracellular alkalinization has long been recognized as a hallmark of plant cell-surface receptor activation, including during pattern-triggered immunity (PTI); yet the mechanisms driving elicitor-induced alkalinization and its role in immune signaling remain unclear. Here, we demonstrate that inhibition of autoinhibited H+-ATPases (AHAs) is required for elicitor-induced extracellular alkalinization. This alkalinization is essential for immune signaling mediated by diverse plasma membrane-localized receptor kinases (RKs) through modulation of ligand-receptor interactions. Notably, RKs transduce elicitor-triggered signaling via BOTRYTIS-INDUCED KINASE 1 (BIK1), which inhibits AHA activity by disrupting AHA-GENERAL REGULATORY FACTOR (GRF) interactions through a conserved phosphorylation event. Interestingly, this pathway is crucial for cell wall damage (CWD) responses involving the RK MALE DISCOVERER 1-INTERACTING RECEPTOR LIKE KINASE 2 (MIK2) and its ligand, SERINE RICH ENDOGENOUS PEPTIDE 18 (SCOOP18). Our findings reveal a conserved phospho-regulatory pathway that governs extracellular alkalinization to coordinate plant immune signaling, offering new insights into plant stress resilience.
Matching journals
The top 5 journals account for 50% of the predicted probability mass.
Similar papers in this journal
- Humidity-driven ABA depletion determines plant-pathogen competition for leaf water 96%
- Fertilization-induced synergid cell death by RALF12-triggered ROS production and ethylene signaling 95%
- Pathogen effector recognition-dependent association of NRG1 with EDS1 and SAG101 in TNL receptor immunity 95%
Similar papers in this journal
- S1 basic leucine zipper transcription factors shape plant architecture by controlling C/N partitioning to apical and lateral organs 95%
- An AINTEGUMENTA phospho-switch controls bilateral stem cell activity during secondary growth 95%
- PIEZO ion channel is required for root mechanotransduction in Arabidopsis thaliana 94%
Similar papers in this journal
- ITPK1 is an InsP6/ADP phosphotransferase that controls systemic phosphate homeostasis in Arabidopsis 95%
- Primary carbohydrate metabolism genes participate in heat stress memory at the shoot apical meristem of Arabidopsis thaliana 93%
- A bacterial effector uncovers a metabolic pathway involved in resistance to bacterial wilt disease 92%
Similar papers in this journal
- Type one protein phosphatases (TOPPs) catalyze EIN2 dephosphorylation to regulate ethylene signaling in Arabidopsis 95%
- ABA homeostasis and long-distance translocation is redundantly regulated by ABCG ABA importers 95%
- Two interacting transcriptional coactivators cooperatively control plant immune responses 94%
Similar papers in this journal
- Cytoplasmic calcium influx mediated by Lr14a regulates stomatal immunity against leaf rust in wheat 95%
- Age-associated growth control modifies leaf proximodistal symmetry and enables leaf shape diversification 94%
- Tissue-autonomous phenylpropanoid production is essential for establishment of root barriers 94%
"Similar papers" are the closest papers from that journal in the model's embedding space. They show what the match is built on, but the ranking comes mostly from a classifier over the whole training set, not from these examples alone.