Insights into the relationship between nasal bacterial composition and susceptibility to early-life respiratory disease: a pilot observational study.
Caparros-Martin, J. A.; Kicic-Starcevich, E.; Agudelo-Romero, P.; Hancock, D. G.; Iosifidis, T.; Karpievitch, Y. V.; Martino, D. J.; Zhang, G.; Silva, D. T.; Bosco, A.; Prescott, S. L.; LeSouef, P.; Kicic, A.; Stick, S.
Show abstract
BackgroundEarly-life susceptibility to viral respiratory infections is associated with long-term respiratory morbidity in children. Currently, no reliable tools exist to predict susceptibility to these infections. Given its role in modulating pathogen virulence and airway inflammation, the endogenous microbiota represents a potential target for prevention. In this pilot study, we investigated whether distinct nasal microbial communities are associated with viral respiratory disease and respiratory phenotypes during the first year of life. MethodsWe analyzed 90 nasal swabs from 55 infants enrolled in the AERIAL study, representing background samples collected at schedule visits ([~]4 months old) and samples from symptomatic episodes. Bacterial profiling was done blinded to clinical data via full-length 16S rRNA sequencing, and bacterial load was quantified using a pan-bacterial TaqMan(R) assay. ResultsNasal bacterial diversity was similar between background and symptomatic swabs, with community composition differences largely driven by inter-individual variation. In paired samples, symptomatic swabs showed reduced diversity but no change in bacterial load. Virus-bacteria interactions were observed in rhinovirus-positive swabs, but not in SARS-CoV-2-positive swabs. Two distinct bacterial endotypes were identified, enriched in either Moraxella or Streptococcus species and differing in alpha diversity. In background swabs, microbial endotypes were not associated with the number of symptomatic swabs or bronchiolitis episodes. We observed a potential sex-specific association between background swabs endotypes and number of wheezing episodes, which warrants further investigation in follow-up studies. ConclusionOur pilot data suggest that the nasal microbiota might influence wheezing outcomes in a sex-specific manner, highlighting the need for larger, longitudinal investigations.
Matching journals
The top 3 journals account for 50% of the predicted probability mass.
Similar papers in this journal
- Microbiota of the pregnant mouse: characterization of the bacterial communities in the oral cavity, lung, intestine, and vagina through culture and DNA sequencing 95%
- Low diversity and instability of the sinus microbiota over time in adults with cystic fibrosis 95%
- Taxonomic and functional shifts in the perinatal gut microbiome of rhesus macaques 95%
Similar papers in this journal
- The gut microbiome and early-life growth in a population with high prevalence of stunting 95%
- A prevalent and culturable microbiota links ecological balance to clinical stability of the human lung after transplantation 95%
- Mechanical ventilation affects respiratory microbiome of COVID-19 patients and its interactions with the host 95%
Similar papers in this journal
- IL-33 controls IL-22-dependent antibacterial defense by modulating the microbiota 93%
- Exhaled aerosol increases with COVID-19 infection, and risk factors of disease symptom severity 92%
- The telencephalon is a neuronal substrate for systemic inflammatory responses in teleosts via polyamine metabolism 92%
Similar papers in this journal
- Pathobiology and dysbiosis of the respiratory and intestinal microbiota in 14 months old Golden Syrian hamsters infected with SARS-CoV-2 93%
- Host- and microbial-mediated mucin degradation differentially shape Pseudomonas aeruginosa physiology and gene expression 93%
- Evidence of MHC class I and II influencing viral and helminth infection via the microbiome in a non-human primate 92%
"Similar papers" are the closest papers from that journal in the model's embedding space. They show what the match is built on, but the ranking comes mostly from a classifier over the whole training set, not from these examples alone.