Spatial Transcriptomics Reveal Developmental Dynamics of the Human Cerebral Cortex and Striatum
Zhang, Y.; Lin, Y.; Shen, X.; Xiao, X.; Song, C.; Shi, X.; Zhou, T.; Li, Y.; Wu, Z.; Zhuang, Z.; Li, C.; Li, M.; Wen, F.; Liu, J.; Cao, L.; Zhang, Q.; Li, Z.-L.; Zhang, S.; Qu, S.; Li, Y.; Yao, J.; Huang, F.; Liu, X.; Deng, Z.; Liu, L.; Xu, X.; Jiao, J.; Zhang, L.; Liu, S.; Zhang, Y.
Show abstract
The human fetal brain undergoes morphological changes that contribute to the development of regional functionalities. However, the features of structural development, the underlying molecular and cellular signatures in the fetal brain remain unclear. With spatial transcriptomics and snRNA-seq, we identified 25 forebrain regions and characterized the dynamic changes in the cortex and striatum during the late first and early second trimesters. In particular, we discovered that temporal lobe enriched NPY-expressing L2/3 EX neuron potentially interacted with L4 EX neurons during cortical expansion and arealization. Additionally, the gyrus and sulcus were developmental asynchronous, in which HOPX and SPARC genes were potentially involved. Further investigation on the striatum showed specific genes and cell types that enriched in patch and matrix compartments, and SST-positive interneurons potentially involved in the development of these structures. Together, our results give insights into the understanding of early fetal brain development.
Matching journals
The top 4 journals account for 50% of the predicted probability mass.
Similar papers in this journal
- Cell-type, single-cell, and spatial signatures of brain-region specific splicing in postnatal development 97%
- A spatial single-cell atlas of the claustro-insular region uncovers key regulators of neuronal identity and excitability 97%
- CTCF mutation at R567 causes developmental disorders via 3D genome rearrangement and abnormal neurodevelopment 96%
Similar papers in this journal
- Defining the molecular identity and morphology of glia limitans superficialis astrocytes in mouse and human 96%
- The molecular genetic landscape of human brain size variation 96%
- Spatiotemporal analysis of gene expression in the human dentate gyrus reveals age-associated changes in cellular maturation and neuroinflammation 95%
Similar papers in this journal
- Integrated single-cell transcriptomic and epigenetic analyses of cell-state transition and lineage commitment in the embryonic mouse cerebellum 97%
- A telencephalon cell type atlas for goldfish reveals diversity in the evolution of spatial structure and cell types 97%
- Single-cell genomics reveals region-specific developmental trajectories underlying neuronal diversity in the human hypothalamus 97%
Similar papers in this journal
- Directed differentiation of functional corticospinal-like neurons from endogenous SOX6+/NG2+ cortical progenitors 96%
- Cellular taxonomy and spatial organization of the ventral posterior hypothalamus reveals neuroanatomical parcellation of the mammillary bodies 96%
- High-throughput mapping of single-cell molecular and projection architecture of neurons by retrograde barcoded labelling 96%
Similar papers in this journal
- Spatially resolved cell atlas of the teleost telencephalon and deep homology of the vertebrate forebrain 96%
- Gene regulatory networks controlling differentiation, survival, and diversification of hypothalamic Lhx6-expressing GABAergic neurons. 95%
- Mitochondrial dysfunction drives a neuronal exhaustion phenotype in methylmalonic aciduria 95%
"Similar papers" are the closest papers from that journal in the model's embedding space. They show what the match is built on, but the ranking comes mostly from a classifier over the whole training set, not from these examples alone.