Back

Immunometabolic dysregulation in depression predates illness onset and associates with lower brain gray matter volume

2025-08-16 psychiatry and clinical psychology Title + abstract only
View on medRxiv
Show abstract

Depression often co-occurs with physical health conditions, including heart disease, diabetes and obesity. While dysregulation of the immunometabolic system is posited to underpin several of these comorbidities, the course of immunometabolic dysregulation in depression and its impact on structural brain changes linked to the disorder remain poorly understood. Using brain imaging and metabolomics data from the UK Biobank, we comprehensively evaluated cross-sectional and longitudinal immunometabol...

Predicted journal destinations

1
Translational Psychiatry
94 training papers
Top 0.8% 14.1%
2
Molecular Psychiatry
84 training papers
Top 0.6% 11.4%
3
Brain, Behavior, and Immunity
35 training papers
#1 11.4%
4
Journal of Affective Disorders
72 training papers
Top 2% 8.7%
5
Psychological Medicine
52 training papers
Top 2% 6.2%
6
NeuroImage: Clinical
77 training papers
Top 3% 5.7%
7
Biological Psychiatry: Cognitive Neuroscience and Neuroimaging
27 training papers
Top 0.9% 5.4%
8
Biological Psychiatry
36 training papers
Top 2% 4.9%
9
Nature Communications
483 training papers
Top 29% 3.7%
10
Scientific Reports
701 training papers
Top 68% 3.7%
11
Biological Psychiatry Global Open Science
23 training papers
Top 2% 1.9%
12
Neuropsychopharmacology
29 training papers
Top 2% 1.9%
13
Frontiers in Psychiatry
56 training papers
Top 6% 1.9%
14
Psychiatry Research
33 training papers
Top 5% 1.5%
15
PLOS ONE
1737 training papers
Top 95% 1.5%
16
Journal of Psychiatric Research
22 training papers
Top 4% 1.3%
17
Schizophrenia Bulletin
21 training papers
Top 3% 1.3%
18
BJPsych Open
24 training papers
Top 4% 1.1%
19
Human Brain Mapping
53 training papers
Top 9% 0.9%
20
eLife
262 training papers
Top 57% 0.7%
21
Neuroscience & Biobehavioral Reviews
19 training papers
Top 4% 0.7%
22
The British Journal of Psychiatry
21 training papers
Top 5% 0.7%
23
Journal of Child Psychology and Psychiatry
18 training papers
Top 4% 0.7%
24
American Journal of Medical Genetics Part B: Neuropsychiatric Genetics
15 training papers
Top 3% 0.7%