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Association between Albumin and Hearing Loss: A Cross-Sectional Study Using Data from the National Health and Nutrition Examination Survey (1999-2012, 2015-2018)

Yiyang, C.; Chenyang, L.; Hongyi, L.; Wei, L.; jiang, j.

2025-08-14 otolaryngology
10.1101/2025.08.13.25333551 medRxiv
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ObjectiveWe investigated the association between albumin levels and hearing loss. MethodsA cross-sectional analysis was conducted using data from the National Health and Nutrition Examination Survey (NHANES) for the periods 1999-2012 and 2015-2018. Participants aged [&ge;]20 years were included. Data on albumin levels, hearing ability, and relevant covariates were collected. ResultsThe final sample comprised 12,133 adults with a mean age of 48.9 {+/-} 17.5 years; 60.9% were non-Hispanic white, and 51.1% were men. Hearing loss was defined as a threshold of [&ge;]20 dB. The odds ratios for low-frequency, speech-frequency, and high-frequency hearing loss were 0.69 (95% CI: 0.56-0.84, p < 0.001), 0.59 (95% CI: 0.49-0.73, p < 0.001), and 0.62 (95% CI: 0.51-0.76, p < 0.001), respectively. ConclusionsThese findings suggest that albumin levels are significantly associated with hearing loss in adults in the United States. However, further research into the underlying mechanisms is needed.

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