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Genetic association of T1D stratified by HLA DR3 and DR4 status reveals heterogeneity in pathways of progression to T1D

2025-08-15 genetic and genomic medicine Title + abstract only
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BackgroundThere are substantial differences in the clinical presentation of type 1 diabetes (T1D) depending on the first-developing autoantibody, although the underlying mechanisms are poorly understood. The DR3-DQ2 (DR3) and DR4-DQ8 (DR4) haplotypes at the MHC locus closely associate with GAD and IAA as the first-developing autoantibody, respectively, and can therefore be used as proxies for first autoantibody development in large cohort studies of T1D cases and controls. MethodsWe performed t...

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