Dietary soy shapes murine microbiota to consolidate the mucosal IgA response through T follicular helper cells
Hattori-Muroi, K.; Maruta, H.; Takahashi, D.; Kinashi, Y.; Hattori, K.; Kabumoto, Y.; Fujimura, Y.; Tsukamoto, S.; Suzuki, K.; Oguchi, H.; Ogihara, Y.; Kodaira, Y.; Hayashi, E.; Takano, K.; Komiyama, S.; Morita, N.; Naganawa-Asaoka, H.; Oya, Y.; Saito, Y.; Ohashi, W.; Kimura, S.; Shinkura, R.; Matsuda, T.; Hase, K.
Show abstract
The commensal microbiota plays a crucial role in shaping mucosal immunity, particularly in the induction of T follicular helper (Tfh) cells and IgA production. Here, we demonstrate that dietary soy elicits a robust Tfh cell and IgA response in Peyers patches of weaning mice. Soy feeding promotes the expansion of two principal commensal bacterial species, Limosilactobacillus reuteri and Muribaculum intestinale. Mechanistically, L. reuteri provides cognate antigens for Tfh cell activation, while M. intestinale functions as an adjuvant by promoting IL-1{beta} production from myeloid cells. The resulting IgA exhibits polyreactivity and enhances protection against Salmonella infection. These findings highlight the specific interplay among dietary components, intestinal microbiota, and mucosal immunity, thereby establishing a diet-microbe-immune axis that shapes host defense in early life. This axis represents a promising therapeutic target for developing novel strategies to enhance resistance to enteric pathogens. Graphical abstract O_FIG O_LINKSMALLFIG WIDTH=170 HEIGHT=200 SRC="FIGDIR/small/669459v1_ufig1.gif" ALT="Figure 1"> View larger version (50K): org.highwire.dtl.DTLVardef@1ae8277org.highwire.dtl.DTLVardef@1f787ceorg.highwire.dtl.DTLVardef@1f51fd6org.highwire.dtl.DTLVardef@1fd3439_HPS_FORMAT_FIGEXP M_FIG C_FIG HighlightsO_LIDietary soy promotes T follicular helper (Tfh) cell and IgA responses in the Peyers patches of weaning mice. C_LIO_LISoy enhances the colonization of two key commensals, Limosilactobacillus reuteri and Muribaculum intestinale, in the small intestine. C_LIO_LIThese two bacteria synergize to drive mucosal immunity: L. reuteri provides cognate antigens, while M. intestinale provides an adjuvant signal by promoting IL-1{beta} production from myeloid cells. C_LIO_LISoy-induced IgA is polyreactive and protects against Salmonella infection. C_LI
Matching journals
The top 5 journals account for 50% of the predicted probability mass.
Similar papers in this journal
- The gut commensal Blautia maintains colonic mucus function under low fiber consumption through short-chain fatty acid-mediated activation of Ffar2 96%
- Dietary fibers benefits on glucose homeostasis require type 2 conventional dendritic cells in mice fed a high-fat diet 96%
- Dietary protein increases T cell independent sIgA production through changes in gut microbiota-derived extracellular vesicles 96%
Similar papers in this journal
- Microbiota epigenetically direct tuft cell differentiation to control type 2 immunity 96%
- A gut commensal protist protects against virus-mediated loss of oral tolerance 96%
- The maternal microbiome regulates infant respiratory disease susceptibility via intestinal Flt3L expression and plasmacytoid dendritic cell hematopoiesis 96%
Similar papers in this journal
- Stratification of enterochromaffin cells by single-cell expression analysis 95%
- Phosphoglycerate mutase regulates Treg differentiation through control of serine synthesis and one-carbon metabolism 94%
- CXXC-finger protein 1 associates with FOXP3 to stabilize homeostasis and suppressive functions of regulatory T cells 94%
"Similar papers" are the closest papers from that journal in the model's embedding space. They show what the match is built on, but the ranking comes mostly from a classifier over the whole training set, not from these examples alone.