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Nanoparticle enriched mass spectrometry proteomics in British South Asians identifies novel variant-protein-disease mechanisms

2025-08-13 genetic and genomic medicine Title + abstract only
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Understanding genetic variation underlying differences in plasma protein levels can elucidate human disease mechanisms, but prior evidence was almost entirely derived from white Europeans using protein-preselected affinity reagents. Here, we integrate exome sequencing and common non-coding variation with untargeted nanoparticle enriched mass spectrometry (MS)-based plasma proteomics (Seer Proteograph XT: n=8067 protein groups) in >1,400 British-Bangladeshi and British-Pakistani individuals. We g...

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