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Stress Ulcer Prophylaxis Prescribing Options for Critically Ill Patients in Hospitals Participating in a Randomized Controlled Trial: A Protocol and Statistical Analysis Plan

2025-08-13 intensive care and critical care medicine Title + abstract only
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BackgroundProton pump inhibitors (PPIs) and histamine-2 receptor antagonists (H2RAs) predominate as stress ulcer prophylaxis (SUP) agents in intensive care units (ICUs). Prescribing patterns may change over time as randomized controlled trials evaluate SUP in critically ill patients. ObjectiveThis study aims to compare site-specific, self-reported SUP prescribing practices before and after the REVISE trial in participating ICUs. MethodsThis is a pre-planned study as part of the REVISE trial (N...

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