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Characterising the effects of genetic liability to autoimmune conditions on pregnancy outcomes using Mendelian Randomization

2025-08-16 obstetrics and gynecology Title + abstract only
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BackgroundAutoimmune conditions are common in women of reproductive age. They are associated with increased risk of adverse pregnancy outcomes; whether this is causal is unclear. Our aim was to explore the effects of autoimmune condition liability on pregnancy outcomes. MethodsWe conducted two-sample Mendelian randomization (MR) to estimate effects of liability to ten autoimmune conditions on nine primary and seven secondary pregnancy outcomes. We used data from the MR-PREG collaboration includ...

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