Thermosensitivity of cellular translation restricts the growth of fission yeast at high temperatures
Akikusa, Y.; Yamaguchi, A.; Funahashi, Y.; Mahayot, F.; Naka, T.; Matsuo, A.; Nakase, Y.; Izawa, S.; Shiozaki, K.; Morozumi, Y.
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Living organisms have thermal limits above which they are unable to operate and survive. Our previous genetic screen identified proteins that impede the high-temperature growth of fission yeast, including the RNA-binding protein Dri1 and a fission yeast-specific protein termed Rhs1. Here, we show that Dri1 and Rhs1 form a complex and physically interact with the Ccr4-Not complex, a master regulator of mRNA metabolism. Gene expression analysis revealed that the Dri1-Rhs1 and Ccr4-Not complexes negatively regulate a set of genes implicated in ribosome biogenesis (Ribi genes). Loss of the Dri1-Rhs1 complex results in the augmented expression of Ribi genes, thereby suppressing the accumulation of 80S monosomes and the growth inhibition under high-temperature conditions. The thermosensitivity of the translational processes may be a determinant of the upper limit of the growth temperature in fission yeast.
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