Understanding of vascular toxicity of indigo naturalis in anti-inflammation application: mendelian randomization and colocalization study
LIU, J.; Liu, C. J.; Xiao, H. T.; Xu, Z. P.
Show abstract
The Chinese herbal medicine indigo naturalis (IN) shows promising potential for treating autoimmune inflammatory diseases. However, its clinical application is limited by vascular toxicity. Using Mendelian randomization analysis, we conducted the first systematic study of INs target-specific vascular risks, revealing causal links between IN exposure and various vascular disorders. Importantly, our findings identify urate as a mediator between IN exposure and deep vein thrombosis outcome. This study provides genetic insights into safety implications for clinical translation study of IN for anti-inflammation applications and guides biomarker monitoring in related trials.
Matching journals
The top 9 journals account for 50% of the predicted probability mass.
Similar papers in this journal
- Risk assessment of drug-induced Long QT Syndrome for some COVID-19 repurposed drugs 90%
- Managing Endothelial Dysfunction in COVID-19: A Pilot, Double-Blind, Placebo-Controlled, Randomized Clinical Trial at the Lebanese American University Medical Center - Rizk Hospital (MEDIC-LAUMCRH) 90%
- HMGB1 correlates with severity and death of COVID-19 patients 90%
Similar papers in this journal
- Investigation of genomic and transcriptomic risk factors in clopidogrel response in African Americans 92%
- DrugWAS: Leveraging drug-wide association studies to facilitate drug repurposing for COVID-19 91%
- Assessment of the acute effects of 2C-B vs psilocybin on subjective experience, mood and cognition 90%
Similar papers in this journal
Similar papers in this journal
- Complex chemical signals dictate Ah receptor activation through the gut-lung axis 92%
- Hydrogen sulfide protects erectile function through stimulation of antioxidant defense in the corpus cavernosum 91%
- Tracer-based metabolomics for profiling nitric oxide metabolites in a 3D microvessel-on-a-chip model 91%
Similar papers in this journal
"Similar papers" are the closest papers from that journal in the model's embedding space. They show what the match is built on, but the ranking comes mostly from a classifier over the whole training set, not from these examples alone.