Back

ME/CFS and PASC Patient-Derived Immunoglobulin Complexes Disrupt Mitochondrial Function and Alter Inflammatory Marker Secretion

2025-08-10 allergy and immunology Title + abstract only
View on medRxiv
Show abstract

Autoimmunity is a key clinical feature in both post-infectious Myalgic encephalomyelitis / chronic fatigue syndrome (ME/CFS) and Post-Acute Sequelae of COVID (PASC). Passive transfer of immunoglobulins from patients sera into mice induces some clinical features of PASC. IgG-induced transfer of disease phenotypes has long been appreciated, yet the exact mechanism of disease development remains largely elusive. Here, we demonstrate that IgG isolated from post-infectious ME/CFS patients selectively...

Predicted journal destinations

1
Frontiers in Immunology
140 training papers
Top 0.1% 22.2%
2
Nature Communications
483 training papers
Top 12% 7.8%
3
Journal of Clinical Investigation
50 training papers
Top 0.2% 5.9%
4
eLife
262 training papers
Top 8% 5.0%
5
Cell Reports Medicine
49 training papers
Top 0.3% 4.2%
6
The Journal of Immunology
19 training papers
Top 0.3% 3.9%
7
Science Immunology
15 training papers
#1 3.9%
8
PLOS ONE
1737 training papers
Top 86% 3.9%
9
Frontiers in Medicine
99 training papers
Top 3% 3.9%
10
JCI Insight
63 training papers
Top 3% 1.9%
11
Cell
28 training papers
Top 0.4% 1.9%
12
Brain
69 training papers
Top 6% 1.9%
13
Scientific Reports
701 training papers
Top 80% 1.9%
14
eBioMedicine
82 training papers
Top 3% 1.5%
15
International Journal of Molecular Sciences
39 training papers
Top 3% 1.3%
16
The Journal of Infectious Diseases
137 training papers
Top 11% 1.3%
17
npj Vaccines
18 training papers
Top 0.3% 1.3%
18
Clinical Infectious Diseases
219 training papers
Top 20% 1.3%
19
Nature
58 training papers
Top 4% 1.3%
20
Journal of Translational Medicine
21 training papers
Top 0.4% 1.3%
21
Arthritis & Rheumatology
21 training papers
Top 0.9% 1.3%
22
mBio
34 training papers
Top 1% 1.2%
23
Annals of the Rheumatic Diseases
23 training papers
Top 1.0% 1.0%
24
Communications Biology
36 training papers
Top 3% 1.0%
25
Cell Reports
25 training papers
Top 1% 1.0%
26
Cell Genomics
34 training papers
Top 6% 0.9%
27
Heliyon
57 training papers
Top 9% 0.9%
28
Nature Medicine
88 training papers
Top 12% 0.9%
29
Vaccines
131 training papers
Top 15% 0.7%
30
Vaccine
140 training papers
Top 11% 0.7%