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Multi-ancestry fine-mapping of the chromosome 17q12-q21 asthma locus identifies independent associations implicating lymphocyte and eosinophil levels in the causal pathway

2025-08-07 allergy and immunology Title + abstract only
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BackgroundAsthma pathophysiology varies by age-of-onset and involves diverse immune processes reflected in white blood cell (WBC) subsets. To investigate the genetic architecture of asthma and potential endophenotypes, we analyzed the chr17q12-q21 locus, a robustly replicated asthma locus, across European (EUR), African (AFR), East Asian (EAS), and South Asian (SAS) ancestry groups from the UK Biobank (UKB) and Biobank Japan (BBJ). The largest EUR sample was further stratified by age-ofonset as ...

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