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Distinct Neurodevelopmental Signatures of Sex-Specific Transcriptome-Based Polygenic Risk Scores for Depression
2025-07-31
genetic and genomic medicine
Title + abstract only
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Major depressive disorder (MDD) impacts females and males differently and post-mortem gene expression profiling reveals distinct transcriptomic signatures of the disorder in each sex. Using genes that are transcriptionally altered in MDD in both sexes, we recently developed a novel transcriptome-based polygenic risk score (tPRS), which had sex-specific associations with brain structure and depressive symptoms in both adolescents and adults. Identifying the neurodevelopmental signatures of geneti...
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