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A lncRNA drives developmentally-timed decay of all members of an essential microRNA family

Grimme, A. L.; Li, L.; Scholl, A.; Donnelly, B. F.; Channamraju, N.; Vieux, K.-F.; Zhou, L.; Seydoux, G.; Xie, M.; McJunkin, K.

2025-07-31 molecular biology
10.1101/2025.07.30.667716 bioRxiv
Show abstract

The spatiotemporal expression patterns of microRNAs (miRNAs) are crucial to their function. Target-directed miRNA degradation (TDMD) is an emerging regulatory module that contributes to these expression patterns wherein a specialized RNA (TDMD trigger) drives miRNA decay through base pairing and resulting recruitment of E3 ubiquitin ligase ZSWIM8/EBAX-1. Extensive base pairing to the miRNA seed region and 3 end has been proposed as a key feature that distinguishes TDMD triggers from conventional mRNA targets of miRNAs, which primarily pair with the seed. Here we identify the long noncoding RNA, tts-2, as a TDMD trigger for mir-35-42, the most abundant miRNA family in C. elegans early embryos. We demonstrate that a single site in tts-2 drives decay through base pairing with the seed sequence shared by all eight family members. A second site in tts-2 supports decay of mir-38 with incomplete seed complementarity. Our findings demonstrate that extended base pairing is not a universal requirement for TDMD, and that TDMD drives developmentally-timed clearance of abundant miRNAs at the exit of C. elegans embryogenesis.

Published in Genes & Development (predicted rank #15) · training set

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