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Distance- and Hierarchy-Dependent Functional Dysconnectivity in Schizophrenia and Its Association with Cortical Microstructure
2025-07-28
psychiatry and clinical psychology
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BackgroundSchizophrenia is associated with widespread functional dysconnectivity, but the spatial scale and structural correlates of these alterations remain unclear. Short-range connectivity, in particular, has received limited attention due to methodological constraints, despite its relevance to local microcircuit dysfunction. MethodsWe applied a vertex-wise, distance-dependent analysis of functional connectivity strength (FCS) to resting-state fMRI data from 86 schizophrenia patients and 99 ...
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