High-resolution multiplexed antibody-omics and interpretable machine learning unveil novel pathogenic mechanisms in kidney transplant rejection

2025-07-27 transplantation Title + abstract only

Show abstract

Antibody-mediated rejection (AbMR), driven by donor-specific alloantibodies (DSAs), is a major cause of late-stage kidney allograft failure, leading to premature graft loss in over half of affected patients. Despite efforts to link DSA features (e.g., HLA-specific IgG titers) to rejection risk, the immune mechanisms distinguishing DSA+ patients who develop AbMR remain unclear. In this first-in-class study, we develop a sample-sparing and cost-effective technique to generate the most comprehensiv...

High-resolution multiplexed antibody-omics and interpretable machine learning unveil novel pathogenic mechanisms in kidney transplant rejection

Predicted journal destinations