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DAXX governs the silencing of LINE1 during spermatogenesis in mice

Li, Z.; Xiong, C.; Shen, J.; Tan, C.; Ma, D.; Chen, J.; Liu, R.; Sun, Q.; Gong, W.; Yuan, W.; Huang, M.; Huang, L.; Tan, Y.; Li, G.; Luo, M.

2025-07-29 developmental biology
10.1101/2025.07.24.666258 bioRxiv
Show abstract

The suppression of transposable elements in germline is critical for safeguarding fertility. Here we identify that the DAXX, a potent transcription repressor and an H3.3 chaperone, is indispensable for transposable elements silencing during spermatogenesis. Male mice with conditional knockout of Daxx in germ cells mediated by Ddx4-cre display delayed meiotic progression, deformed and reduced production of sperms, and an age-dependent decline in fertility. The ablation of DAXX results in activation of evolutionarily young LINE1 and ERVs subfamilies. Mechanistically, DAXX interacts with DMAP1 to maintain DNA methylation of LINE1 in meiotic cells. In summary, this study identifies DAXX as a previously unknown regulator of spermatogenesis and demonstrates that it functions as an epigenetic regulator to maintain the silencing the young LINE1 by DNA methylation.

Published in Nucleic Acids Research (predicted rank #16) · training set

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