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Anti-TRIM72 Autoantibodies in Idiopathic Inflammatory Myopathies
2025-07-24
rheumatology
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Background and PurposeTripartite motif-containing protein 72 (TRIM72) mediates tissue-repair following injury in several organs, including muscle and lung. Autoantibodies directed against TRIM72 (anti-TRIM72) have been identified in patients with idiopathic inflammatory myopathies (IIM) and disrupt TRIM72 function in vitro. We hypothesized that IIM patients positive for anti-TRIM72 antibodies would have a more severe clinical phenotype. MethodsSera from IIM patient (antisynthetase syndrome [ASy...
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