The Effectiveness and Cost-Effectiveness of CashPlus Interventions to Prevent Acute Malnutrition in Somalia: Evidence from an Adaptive Cluster Randomized Control Trial

BackgroundAcute malnutrition affects millions of children under five (U5) and pregnant and lactating women (PLW) globally, especially in humanitarian settings. Although "CashPlus" interventions - cash or food transfers combined with complementary components - are widely implemented, evidence remains limited on which combinations and durations are most effective at preventing acute malnutrition. MethodsWe conducted a three-arm cluster-randomized trial within Save the Childrens CashPlus for Nutrition program in Somalia. Monthly support was provided as: (1) cash alone (Arm 1), (2) cash plus social and behavior change communication (SBCC; Arm 2), or (3) cash plus an additional cash top-up (Arm 3). Thirty-three villages were randomized across arms, targeting [~]1,500 households. Primary outcomes included prevalence and incidence of acute malnutrition in children 6-59 months and mothers, assessed at baseline, midline (3 months), and endline (6 months), alongside economic evaluations of cost and cost-effectiveness. Market monitoring and qualitative data were also conducted. ResultsChild acute malnutrition prevalence was approximately 15% in each arm at baseline. After 3 months, prevalence declined by 2.0 percentage points in Arm 1 to 13.0% (95% CI: 10.3%-16.1%), representing a relative reduction of 13.3%. In Arm 2, prevalence declined by 5.9 percentage points to 9.1% (6.8%-11.8%), a relative reduction of 39.3%. In contrast, prevalence in Arm 3 remained essentially unchanged, with an increase to 15.1% (12.1%-18.6%). By endline, there was little change from midline in all arms. Maternal malnutrition improved most in Arm 2, but differences were not statistically significant. All arms showed improvements in dietary diversity and food security, but only Arm 2 achieved sustained nutrition gains. Household livelihood conditions appeared to improve overall though monthly expenditures nearly doubled. Arm 2 was the most effective and cost effective. ConclusionAdding SBCC to cash transfers significantly improved child nutrition compared to cash alone, highlighting that integrated approaches can enhance nutritional outcomes and cost-effectiveness in humanitarian settings. RegistrationThe cluster-RCT was registered retrospectively at ClinicalTrials.gov on October 14, 2025, ID: NCT06642012.