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Multi-ancestry polygenic risk scores for the prediction of type 2 diabetes and complications in diverse ancestries.
2025-07-23
genetic and genomic medicine
Title + abstract only
View on medRxiv
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BackgroundPolygenic risk scores (PRSs) improve type 2 diabetes (T2D) prediction beyond clinical risk factors but perform poorly in non-European populations, where T2D burden is often higher, undermining their global clinical utility. MethodsWe conducted the largest global effort to date to harmonize T2D genome-wide association study (GWAS) meta- analyses across five ancestries--European (EUR), African/African American (AFR), Admixed American (AMR), South Asian (SAS), and East Asian (EAS)--inclu...
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