Complexes between Netrin G Ligands and Chiral Nanoparticles Promote Axons Regeneration under Near-Infrared Illumination
Kotov, N. A.; Qu, A.; Sun, M.; Xu, X.; Li, S.; Hao, C.; Veksler, M.; Shi, B.; Colombari, F. M.; Shi, W.; de Moura, A. F.; Dong, J.; Kuang, H.; Xu, L.; Xu, C.
Show abstract
Chiral nanoparticles combine functionalities of inorganic materials and large biomacromolecules enabling stimulation of neurons. However, multiple challenges remain in their use for central nervous system including identifying suitable cell signaling pathways and traversing the blood-brain barrier. In this study, we show that glutathione-coated Ni(OH)2 nanoparticles form nanoscale complexes with netrin-G1 ligands (NGL-1), critical for neuronal regeneration. NGL-1 features a semispherical pocket with a 2.5 nm radius of curvature, fitting well with nanoparticles sized 3 {+/-} 1.2 nm. D-NPs with D-glutathione surface ligands activate D-glutathione receptors on epithelial cells, facilitating their transport into the brain. When illuminated with 980 nm light, the nanoparticle-protein complex stimulates axon regeneration through localized IGF-1 production. This approach successfully regenerated (a) hippocampal neurons in Alzheimers disease mice and (b) dorsal root ganglion neurons in spinal cord-injured mice. The nanoparticles were thoroughly tested for safety and excreted intact. The local, rather than systemic, IGF-1 upregulation minimizes its side effects.
Matching journals
The top 4 journals account for 50% of the predicted probability mass.
Similar papers in this journal
Similar papers in this journal
- In situ measurement of intracellular thermal conductivity using heater-thermometer hybrid diamond nanosensor 95%
- BBB pathophysiology independent delivery of siRNA in traumatic brain injury 93%
- Magnetically induced magnetosome chain (MAGiC):A biogenic magnetic-particle-imaging tracer with high performance and navigability 93%
Similar papers in this journal
- Noninvasively real-time monitoring in-vivo immune cell and tumor cell interaction by NIR-II nanosensor 95%
- From the Roundabout of Molecular Events to Nanomaterial-Induced Chronic Inflammation Prediction 95%
- Defect-Engineered Metal-Organic Frameworks as Nanocarriers for Pharmacotherapy: Insights into Intracellular Dynamics at The Single Particle Level 94%
"Similar papers" are the closest papers from that journal in the model's embedding space. They show what the match is built on, but the ranking comes mostly from a classifier over the whole training set, not from these examples alone.