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Altered CSF Tryptophan-Kynurenine Pathway Metabolism in Multiple System Atrophy: Distinct from Classic Microglial Markers

2025-07-17 neurology Title + abstract only
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BackgroundAlterations in tryptophan (TRP)-serotonin metabolism have been implicated in multiple system atrophy (MSA). However, the involvement of the TRP-kynurenine (KYN) pathway, which is associated with neuroinflammatory and neuroprotective processes, is elusive. ObjectivesTo investigate tryptophan metabolism in cerebrospinal fluid (CSF), we examined the relationships between metabolites and their associations with clinical biomarkers reflecting microglial activation and axonal injury in MSA ...

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