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An extended β-finger motif is near-ubiquitous in kinase fusion proteins

Powell, O. R.; Gilbert, D.; Wulff, B. B. H.

2025-08-03 plant biology
10.1101/2025.07.14.664643 bioRxiv
Show abstract

Kinase fusion proteins (KFPs) are immune receptors that confer disease resistance in wheat (Triticum aestivum) and barley (Hordeum vulgare). We discovered that KFPs with a confirmed function share an extended {beta}-finger motif, a Poaceae-specific feature that originated [~]98 million years ago. The genes encoding these receptors are among the most highly expressed within the plant KFP repertoire, suggesting that elevated transcript abundance is a hallmark of their disease resistance function.

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