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Much higher covariation with foveation timing by superior colliculus than primary visual cortical neuronal activity

Trottenberg, C.; Yu, Y.; Zhang, T.; Baumann, M. P.; Malevich, T.; Prasad, S.; Hafed, Z. M.

2025-07-16 neuroscience
10.1101/2025.07.10.664256 bioRxiv
Show abstract

The superior colliculus (SC) is a potent driver for orienting movements, but it also possesses short-latency visual responses. Even though such responses largely derive from direct primary visual cortical (V1) input, their relationship to V1 activity has never been analyzed with the same experimental subjects and stimuli. Here, we revisited pioneering observations that trial-by-trial variability in either SC or V1 visual responses may predict eye movement timing variability. We found that V1 covariation with behavioral variability was virtually non-existent in comparison to the SC, whether with respect to visual response onset latency, visual response strength, or pre-stimulus state. By far, our largest predictor of behavioral variability was visual response strength in SC visual-motor neurons. These results suggest that the SC reformats its sensory inputs for exploitation of the SCs proximity to the motor periphery; V1 aids in jumpstarting the sensing process, but the SC much more directly supports visually-driven orienting.

Published in iScience (predicted rank #10) · training set

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