Light-up nanostructures with allosteric DNA mimics of GFP
Zhang, T.; Qian, X.; Zhang, J.; Cui, H.; Bai, T.; Wang, W.; Wang, Y.; Gao, Z.; Han, D.; Zeng, W.; Wei, B.
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In this study, we present a systematic approach for the rational design of synthetic allosteric DNA aptamers. This methodology enables precise control over the allosteric ON-OFF transition in fluorescent DNA aptamers, allowing for the engineering of aptamers with highly tunable fluorescent properties. When combined with toehold-mediated strand displacement, we have developed a series of allosteric aptamers in which the target sequence functions as a specific allosteric modulator. Furthermore, these aptamers have been applied in synthetic DNA computing and in the construction of responsive nanostructures that light up upon activation.
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