Modulating Cardiac-Gut Microbiome Interaction Post-Myocardial Infarction with Engineered Bacteria
Madaan, T.; Nieman, M.; Rakheja, T.; Siddiqui, N.; Gherardini, D.; Sertorio, M.; Kamble, N.; Thomas, S.; Hartman, A.; Koch, S.; Knipper, L.; Marino, V. A.; Sadayappan, S.; Lorenz, J. N.; Konhilas, J. P.; Kotagiri, N.
Show abstract
The gut microbiome plays a critical role in the pathophysiology of acute myocardial infarction (MI). MI events significantly impact intestinal integrity which results in leakage of bacterial products into the systemic circulation. We demonstrate that MI not only compromises intestinal integrity, leading to systemic leakage of bacterial products like LPS, but also results in the translocation and colonization of live, intact gut bacteria in the MI heart - a novel aspect of the heart-gut axis. Our initial findings with natural murine gut microbiome were substantiated using orally administered E. coli Nissle 1917 (EcN), as a tracer bacterium. Furthermore, we engineered EcN to express the microbial anti-inflammatory molecule (MAM) derived from the probiotic Faecalibacterium prausnitzii. Treatment with this engineered strain, EcN-MAM, led to significantly improved survival and cardiac function in MI mice. This was attributed to enhanced gut barrier integrity, resulting in reduced systemic bacterial permeation and subsequent inflammation. These findings shed light on a previously unrecognized dimension of the heart-gut axis and highlight the potential of microbiome-based interventions in MI management.
Matching journals
The top 7 journals account for 50% of the predicted probability mass.
Similar papers in this journal
- Mitochondrial CaMKII causes metabolic reprogramming, energetic insufficiency, and dilated cardiomyopathy 95%
- Ezh2 as an epigenetic checkpoint regulator during monocyte differentiation: a potential target to improve cardiac repair after myocardial infarction 95%
- Cardiomyocyte Contractile Impairment in Heart Failure Results from Reduced BAG3-mediated Sarcomeric Protein Turnover 95%
Similar papers in this journal
- 3D Bioprinted Fat-Myocardium Model Unravels the Role of Adipocyte Hypertrophy in Atrial Dysfunction 93%
- Distinct stress-dependent signatures of cellular and extracellular tRNA-derived small RNAs (tDRs) 93%
- Genetically-programmed Hypervesiculation of Lactiplantibacillus plantarum Increases Production of Bacterial Extracellular Vesicles with Therapeutic Efficacy in a Preclinical Inflammatory Bowel Disease Model 93%
Similar papers in this journal
- Splenic CD169 + Tim4 + Marginal Metallophilic Macrophages Are Essential for Wound Healing After Myocardial Infarction 96%
- CD206 + IL-4Rα + MACROPHAGES ARE DRIVERS OF ADVERSE CARDIAC REMODELING IN ISCHEMIC CARDIOMYOPATHY 95%
- Agrin promotes coordinated therapeutic processes leading to improved cardiac repair in pigs 95%
Similar papers in this journal
- Altered hepatic metabolism mediates sepsis preventive effects of reduced glucose supply in infected preterm newborns 95%
- Identification of pharmacological inducers of a reversible hypometabolic state for whole organ preservation 95%
- Increasing heart vascularisation after myocardial infarction using brain natriuretic peptide stimulation of endothelial and WT1+ epicardium-derived cells. 95%
Similar papers in this journal
"Similar papers" are the closest papers from that journal in the model's embedding space. They show what the match is built on, but the ranking comes mostly from a classifier over the whole training set, not from these examples alone.