Genome-wide insights into generalised anxiety using a dimensional symptom severity approach
Skelton, M.; Mitchell, B. L.; Assary, E.; Li, D.; Morneau-Vaillancourt, G.; Murphy, A. E.; ter Kuile, A. R.; Wang, R.; Adams, M. J.; Byrne, E. M.; Corfield, E. C.; Grimes, P. Z.; Hannigan, L. J.; Hu, J.; Koiv, K.; Kwong, A. S.; Papiol, S.; Pettersen, J. H.; Pistis, G.; Castelao, E.; Strom, N. I.; van der Most, P. J.; Anxiety Disorders Working Group of the Psychiatric Genomics Consortium, ; GLAD+ authors, ; Lifelines Cohort Study, ; NIHR Bioresource, ; Protect-AD Consortium, ; Andreassen, O. A.; Erhardt-Lehmann, A.; Havdahl, A.; Skene, N.; Verhulst, B.; Weber, H.; Armour, C.; Ask, H.; Cope
Show abstract
We performed a genome-wide association meta-analysis of generalised anxiety symptom severity in 693,869 individuals of European ancestry from 14 cohorts. We identified 80 independent genome-wide significant variants within 74 loci, 39 of which were novel for anxiety. SNP-based heritability was 5.9% (SE = 0.15%). Polygenic scores were significantly associated with anxiety symptom severity and disorder in European, African, and South Asian ancestry samples (r2=1.2%-2.9%). Significant genetic correlations were estimated with numerous mental and physical health traits, including case-control anxiety, neuroticism and depression (rg=0.71-0.86), irritable bowel syndrome (rg=0.57), coronary artery disease, endometriosis, and migraine (rg=0.20-0.27). Gene-based and pathway analyses implicated synaptic and axonal processes, with enriched expression in the brain. These findings highlight the additional value of a quantitative approach in anxiety genetics.
Matching journals
The top 5 journals account for 50% of the predicted probability mass.
Similar papers in this journal
Similar papers in this journal
- Immunological Drivers and Potential Novel Drug Targets for Major Psychiatric, Neurodevelopmental, and Neurodegenerative Conditions 95%
- Leveraging genome-wide data to investigate differences between opioid use vs. opioid dependence in 41,176 individuals from the Psychiatric Genomics Consortium 94%
- Genetic neurodevelopmental clustering and dyslexia 94%
Similar papers in this journal
- Genetic variants associated with cross-disorder and disorder-specific risk for psychiatric disorders are enriched at epigenetically active sites in peripheral lymphoid cells 95%
- Polygenic architecture of brain structure and function, behaviors, and psychopathologies in children 94%
- Whole Genome Sequencing Analysis Of Body Mass Index Identifies Novel African Ancestry-Specific Risk Allele 94%
Similar papers in this journal
- Transcriptional-Regulatory Convergence Across Functional MDD Risk Variants Identified by Massively Parallel Reporter Assays 95%
- Are psychiatric disorders risk factors for COVID-19 susceptibility and severity? a two-sample, bidirectional, univariable and multivariable Mendelian Randomization study 94%
- Genomic Influences on Self-Reported Childhood Maltreatment 93%
"Similar papers" are the closest papers from that journal in the model's embedding space. They show what the match is built on, but the ranking comes mostly from a classifier over the whole training set, not from these examples alone.