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Residual legacy immunity from prior smallpox vaccination and serological evidence of asymptomatic mpox transmission in a West African population

2025-07-08 allergy and immunology Title + abstract only
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The 2022 multi-country mpox outbreak, driven by MPXV Clade IIb has spread globally to over 100 countries, posing a new threat to global public health. Smallpox vaccination was discontinued in 1980 following global elimination with recent reports demonstrating evidence of asymptomatic infections particularly in individuals unlikely to have received a smallpox vaccine. To determine whether residual vaccination-derived immunity still shapes infection risk and to characterise population level burden...

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