Psilocybin has no immediate or persistent analgesic effect in acute and chronic mouse pain models
Gregory, N. S.; Girard, T. E.; Ram, A.; Casey, A. B.; Malenka, R. C.; Tawfik, V. L.; Heifets, B. D.
Show abstract
The psychedelic psilocybin may have lasting therapeutic effects for patients with chronic pain syndromes. Some clinical and preclinical data suggest these putative benefits derive from direct analgesic effects. However, this possibility has not been comprehensively tested in preclinical models. Here, we show that psilocybin is not analgesic over a range of doses across multiple pain assays and models of acute and chronic inflammatory, neuropathic, or musculoskeletal pain in mice.
Matching journals
The top 1 journal accounts for 50% of the predicted probability mass.
Similar papers in this journal
- Amygdalar Calcitonin Gene-Related Peptide Driven Effects of Cold Sensitivity Induced by Peripheral Neuropathy in Mice 98%
- De novo expression of neuropeptide Y in sensory neurons does not contribute to peripheral neuropathic pain 97%
- Protease-Activated Receptor 2 (PAR2) expressed in sensory neurons contributes to signs of pain and neuropathy in paclitaxel treated mice 97%
Similar papers in this journal
- Digging deeper into pain - an ethological behavior assay correlating well-being in mice with human pain experience. 96%
- Lysophosphatidyl-choline 16:0 mediates persistent joint pain through Acid-Sensing Ion Channel 3: preclinical and clinical evidences 95%
- The role of amygdala calcitonin gene-related peptide receptors on the development of persistent bladder pain in mice. 95%
Similar papers in this journal
- Inhibiting Spinal Cord-Specific Hsp90 Isoforms Reveals a Novel Strategy to Improve the Therapeutic Index of Opioid Treatment 96%
- Corticotropin-Releasing Factor Neurons in the Bed Nucleus of the Stria Terminalis Differentially Influence Pain Processing and Modulation in Male and Female Mice 95%
- The Secretomes of Painful Versus Nonpainful Human Schwannomatosis Tumor Cells Differentially Influence Sensory Neuron Gene Expression and Sensitivity 94%
Similar papers in this journal
- A 'double-edged' role for type-5 metabotropic glutamate receptors in pain disclosed by light-sensitive drugs 95%
- Contextual control of conditioned pain tolerance and endogenous analgesic systems: Evidence for sex-based differences in endogenous opioid engagement 95%
- Protective role of neuronal and lymphoid cannabinoid CB2 receptors in neuropathic pain 95%
Similar papers in this journal
- ATP-Gated Potassium Channels Contribute to Ketogenic Diet-Mediated Analgesia in Mice. 95%
- Eukaryotic initiation factor 3d Regulates Context-Dependent Pain Hypersensitivity Through the Integrated Stress Response 94%
- FL/FLT3 signaling enhances mechanical pain hypersensitivity through Interleukin-1 beta (IL-1β) in male mice 93%
"Similar papers" are the closest papers from that journal in the model's embedding space. They show what the match is built on, but the ranking comes mostly from a classifier over the whole training set, not from these examples alone.