Investigating associations between hearing, cognition, and social isolation using the Hertfordshire Ageing Study

ObjectivesO_LITo investigate whether hearing threshold predicts cognitive score 10 years later using the Hertfordshire Ageing Study data. C_LIO_LITo investigate whether hearing threshold predicts social isolation score 10 years later using the Hertfordshire Ageing Study data. C_LI MethodsThe Hertfordshire Ageing Study (HAS) is a longitudinal cohort study that measured hearing via pure tone audiometry at two time points, and social isolation and cognition variables at the second time point. Linear regression was implemented for both objectives using an unadjusted model, a model controlling for age and gender, and a model controlling for all confounders (sociodemographic, lifestyle and clinical characteristics) relating to the exposure and outcome variables. Results231 participants were included in the final analysis. There was no statistically or clinically significant evidence found to indicate hearing threshold at timepoint 1 predicting cognitive score at timepoint 2, and hearing threshold at timepoint 1 predicting social isolation at timepoint 2. ConclusionThe lack of evidence of an association despite strong theoretical evidence, may be due to selection bias within the overall cohort study and the sensitivity of the outcome measures used for social isolation and cognition.