Development and validation of the Dysarthria Impact Scale

BackgroundImpaired speech due to dysarthria significantly impacts quality of life. Patient-reported outcomes (PROs) offer critical insight into the lived experience of communication disability and are increasingly central to regulatory frameworks for patient-focused drug development. ObjectivesTo develop and validate the Dysarthria Impact Scale (DIS), a brief PRO designed to assess the impact of motor speech disorders on quality of life across neurological conditions. MethodsA multi-site, cross-sectional study was conducted with 244 participants, including individuals with Huntingtons disease, Parkinsons disease, hereditary ataxias, and head and neck cancer, along with healthy controls. The 22-item DIS was developed using expert input and patient feedback and evaluated alongside reference tools (Voice Handicap Index and SF-36). Item reduction procedures yielded two shorter versions (DIS-17 and DIS-6). Validity, reliability, and sensitivity/specificity analyses were performed, and minimal clinically important differences (MCIDs) were estimated using distribution-based methods. ResultsAll DIS versions showed strong convergent validity with the VHI (r = -0.85) and SF-36 (r = 0.72) and were correlated with blinded perceptual speech ratings. DIS-17 and DIS-6 achieved comparable sensitivity (0.93 and 0.88) and specificity (0.84 and 0.86, respectively). Test-retest reliability was high (r = 0.98), with WSSD estimates ranging from 4.0 to 10.6 across groups. Estimated MCIDs ranged from 5 to 15 points. Group differences were observed, with lower DIS scores in ataxia and Parkinsons disease compared to Huntingtons disease. ConclusionsThe DIS is a valid, reliable, and practical PRO for quantifying the impact of dysarthria on quality of life. It is suitable for clinical monitoring and clinical trial use, with sensitivity to disease-related variation and change.