Modular, reconfigurable fiber-based neural probe (MoRF probe) with interchangeable and tunable optical waveguide, microfluidic channel, and microelectrodes
Huang, H.; Liu, Y.; Yang, S.; Hu, S.; English, D. F.; Jia, X.
Show abstract
Neuroscience is at an exciting juncture at which large-scale in vivo electrophysiology, including in humans, is intersecting symbiotically with revolutionary computational and statistical methods. Maintaining this relationship requires increasingly advanced neural probes for multimodal interrogation of neural circuitry (e.g. perturbation experiments are of value to computational modeling). Here, we developed a low cost modular and reconfigurable recording and stimulation fiber-based neural probe (MoRF) fabricated via a first step thermal drawing process (TDP) and a second step thermal tapering process (TTP). We demonstrated the device modularity and reconfigurability in several functional variations of the same device, as well as the ability to adjust the distance between different sensing elements. We validated the electrical, optical and microfluidic drug delivery performance of the MoRF probe and demonstrated its in vivo electrophysiological recording and optogenetic stimulation capabilities in awake mice.
Matching journals
The top 6 journals account for 50% of the predicted probability mass.
Similar papers in this journal
- A Photonic Biosensor-Integrated Tissue Chip Platform for Real-Time Sensing of Lung Epithelial Inflammatory Markers 96%
- A microphysiological system for parallelized morphological and electrophysiological read-out of 3D neuronal cell culture 95%
- Leveraging the Elastic Deformability of Polydimethylsiloxane Microfluidic Channels for Efficient Intracellular Delivery 95%
Similar papers in this journal
Similar papers in this journal
- Scalable, flexible carbon fiber electrode thread arrays for three-dimensional spatial profiling of neurochemical activity in deep brain structures of rodents 95%
- Label-Free Optical Mapping for Large-Area Biomechanical Dynamics of Multicellular Systems 95%
- Hollow ring-like flexible electrode architecture enabling subcellular multi-directional neural interfacing 95%
Similar papers in this journal
- Remote-Controlled Wireless Bioelectronics for Fluoxetine Therapy to Promote Wound Healing in a Porcine Model 96%
- Transparent and stretchable metal nanowire composite recording microelectrode arrays 96%
- Spatiotemporal control of a multilayered co-axial flow in a 3D printed microchannel with cascaded nozzles 93%
Similar papers in this journal
- Customizing Multifunctional Neural Interfaces through Thermal Drawing Process 98%
- Potential of Photoelectric Stimulation with Ultrasmall Carbon Electrode on Neural Tissue: New Directions in Neuromodulation Technology Development 94%
- Multifunctional Materials Strategies for Enhanced Safety of Wireless, Skin-Interfaced Bioelectronic Devices 94%
"Similar papers" are the closest papers from that journal in the model's embedding space. They show what the match is built on, but the ranking comes mostly from a classifier over the whole training set, not from these examples alone.