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The Golgi Apparatus as an Arbiter of Oncofetal Reprogramming: A Systematic Review and Meta-Analysis Linking Embryonic Germ Layer Origin to the Post-Translational Modification Landscape of Cancer

2025-06-30 oncology Title + abstract only
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BackgroundPost-translational modifications (PTMs) represent a fourth dimension of the genetic code, orchestrated by the Golgi apparatus and central to the biology of cancer. The prevailing paradigm of oncofetal reprogramming posits that cancer cells reactivate embryonic developmental programs to drive tumorigenesis; however, the lineage-specific nature of this reversion remains incompletely defined. This review advances and systematically evaluates the hypothesis that the cancer PTM landscape is...

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