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Direct and Indirect Genetic Effects of Birthweight Predisposition on Child DNA Methylation at Birth

2025-06-24 genetic and genomic medicine Title + abstract only
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BackgroundBirthweight is heritable and strongly associated with epigenetic differences at birth. It is unclear whether a genetic birthweight score is associated with DNA methylation (DNAm) and, if so, whether through direct genetic effects (i.e., child genotype) or indirect genetic effects (i.e., parental genotype, independent of child genotype), which are suspected to be mediated by the prenatal environment (e.g. metabolic factors). MethodsWe constructed polygenic scores (PGS) for birthweight ...

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