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Sex-Dependent Relationships Between PFAS and Placental Transcriptomics Identified by Weighted Gene Co-Expression Analysis

2025-06-24 occupational and environmental health Title + abstract only
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BackgroundPer- and polyfluoroalkyl substances (PFAS) are environmental toxicants associated with adverse neonatal outcomes. The exact mechanisms by which PFAS impairs neonatal health are undefined, but the placenta is a likely target. ObjectiveWe applied a systems biology approach to identify placental RNA co-expression modules (gene sets) associated with PFAS exposure and birth weight. MethodsPlacental tissue samples (n = 147) from the GLOWING study underwent RNA-sequencing, and PFAS concentr...

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