Personal night light exposure predicts incidence of cardiovascular diseases in >88,000 individuals

ImportanceLight at night causes circadian disruption, which is a known risk factor for adverse cardiovascular outcomes. However, it is not well understood whether personal light exposure patterns predicts and individuals risk of cardiovascular diseases. ObjectiveTo assess whether day and night light exposure predicts incidence of cardiovascular diseases, and whether relationships of light with cardiovascular diseases differ according to genetic susceptibility, sex, and age. DesignProspective cohort study. SettingUnited Kingdom. ParticipantsN=88,905, age (M{+/-}SD) = 62.4{+/-}7.8 years, 56.9% female. ExposureApproximately 13 million hours of personal light exposure data, tracked by wrist-worn light sensors (one week each). Main Outcomes and MeasuresIncidence of coronary artery disease, myocardial infarction, heart failure, atrial fibrillation, and stroke, derived from UK National Health Service records, across a 9.5-year follow-up after light tracking. ResultsPeople with the brightest nights (90-100th percentiles) had significantly higher risks of developing coronary artery disease (adjusted-HR range: 1.23-1.32), myocardial infarction (aHRs: 1.42-1.47), heart failure (aHRs: 1.45-1.56), atrial fibrillation (aHRs: 1.28-1.32), and stroke (aHRs: 1.28-1.30), compared to people with dark nights (0-50th percentiles). These relationships were robust after adjusting for established risk factors for cardiovascular health, including physical activity, smoking, alcohol, diet, sleep duration, socioeconomic status, and polygenic risk. Relationships of night light with risk of heart failure and coronary artery disease were stronger for women, and relationships of night light with risk of heart failure and atrial fibrillation were stronger for younger individuals in this cohort. Conclusions and RelevanceNight light exposure was a significant risk factor for developing cardiovascular diseases in this cohort. In addition to current preventative measures, avoiding light at night may be a useful strategy for reducing risks of cardiovascular diseases. Key Points QuestionDoes personal light exposure predict incidence of cardiovascular diseases? FindingsIn this study of [~]89,000 adults aged >40 years, exposure to brighter light at night predicted higher incidence of coronary artery disease, myocardial infarction, heart failure, atrial fibrillation, and stroke, independent of established cardiovascular risk factors. MeaningAvoiding exposure to night light may lower risk for cardiovascular diseases.