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Development and Validation of a Type 1 Diabetes Multi-Ancestry Polygenic Score
2025-06-22
endocrinology
Title + abstract only
View on medRxiv
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ObjectivePolygenic scores strongly predict type 1 diabetes risk, but most scores were developed in European-ancestry populations. In this study, we developed a multi-ancestry polygenic score to accurately predict type 1 diabetes risk across diverse populations. Research Design and MethodsWe used recent multi-ancestry genome-wide association studies to create a type 1 diabetes multi-ancestry polygenic score (T1D MAPS). We trained the score in the Mass General Brigham (MGB) Biobank (372 individua...
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